Factor H complements AMD

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General H - matrices and their Schur complements

The definitions of θ-ray pattern matrix and θ-ray matrix are firstly proposed to establish some new results on nonsingularity/singularity and convergence of general H-matrices. Then some conditions on the matrix A ∈ Cn×n and nonempty α ⊂ 〈n〉 = {1, 2, . . . , n} are proposed such that A is an invertible H-matrix if A(α) and A/α are both invertible H-matrices. Furthermore, the important results o...

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Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.

PURPOSE Complement factor H (Cfh) is a key regulator of the alternative complement pathway. A Cfh variant (Y402H) increases the risk for AMD. The purpose of this study was to develop a pathophysiologically relevant animal model of AMD based on this genetic risk factor. METHODS The authors generated chimeric Cfh transgenic mouse lines using two constructs consisting of the human CFH sequence f...

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Special H-matrices and their Schur and diagonal-Schur complements

It is well known, see [D. Carlson, T. Markham, Schur complements of diagonally dominant matrices, Czech. Math. Schur complement of a strictly diagonally dominant matrix is strictly diagonally dominant , as well as its diagonal-Schur complement. Also, if a matrix is an H-matrix, then its Schur complement and diagonal-Schur complement are H-matrices, too, see [J. Liu, Y. Huang, Some properties on...

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Further results on H-matrices and their Schur complements

It is well-known [D. Carlson, T. Markham, Schur complements of diagonally dominant matrices, Czech. Math. J. 29 (104) (1979) 246–251, [1]] that the Schur complement of a strictly diagonally dominant matrix is strictly diagonally dominant. Also, if a matrix is an H-matrix, then its Schur complement is an H-matrix, too [J. Liu, Y. Huang, Some properties on Schur complements of H-matrices and diag...

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Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis

The purpose of this study is to investigate whether the Y402H polymorphism (rs1061170, a T-to-C transition at amino acid position 402) in the complement factor H (CFH) gene have a pharmacogenetics effect on the anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD). We performed a meta-analysis using databases including PubMed and EMBASE ...

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ژورنال

عنوان ژورنال: Science-Business eXchange

سال: 2011

ISSN: 1945-3477

DOI: 10.1038/scibx.2011.1136